Cochran Lab
Cochran Lab
NEWS AND EVENTS

2014

Engineered protein therapeutic stops the spread of cancer.
In a paper in Nature Chemical Biology, an experimental therapy stopped the metastasis of breast and ovarian cancers in lab mice, pointing toward a safe and effective alternative to chemotherapy.

LUNGevity Foundation Research Award 
Alejandro Sweet-Cordero and Jennifer Cochran were awarded a LUNGevity Targeted Therapeutics Grant for their project entitled: “Protein engineering to target tumor-stroma interactions in non-small cell lung cancer.”

Wallace H. Coulter Translational Partnership Award for a new immunotherapy approach
Jennifer Cochran and Nicolas Currier receive funding to develop new protein-based biologics for cancer immunotherapy applications, in collaboration with K. Dane Wittrup, MIT

Engineered ‘molecular flashlight’ illuminates brain tumors in mice. See the press release.
In a publication in the Proceedings of the National Academy of Science, the labs of Jennifer Cochran and Matthew Scott demonstrated that an engineered knottin protein can target and illuminate intracranial tumors in mouse models of medulloblastoma.

The Cochran lab welcomes Jeff Glasgow as a NIST postdoctoral fellow and James Kintzing for a summer rotation.

The Cochran lab welcomes Arvind Kannan, Shelley Ackerman, Sung Jin Park, and Amanda Rabe as new graduate student researchers.

Stanford Institute for Chemical Biology/SLAC Seed Grant Awarded
Jennifer Cochran and Irimpan Mathews (SLAC) are awarded a grant for their project entitled: “Structural basis for high-affinity binding of a potent engineered angiogenesis inhibitor”

2013

The Cochran lab welcomes Julie Fogarty and Amanda Rabe to the lab for a winter quarter rotation.

The Cochran lab welcomes Shelley Ackerman, Nathan Fastman, and Sungjin Park to the lab for a fall quarter rotation.

Engineered ‘molecular flashlight’ illuminates brain tumors in mice
In a publication in the Proceedings of the National Academy of Science, the labs of Jennifer Cochran and Matthew Scott demonstrated that an engineered knottin protein can target and illuminate intracranial tumors in mouse models of medulloblastoma. See the press release.

Stanford Institute for Chemical Biology/SLAC Seed Grant Awarded
Jennifer Cochran and Irimpan Mathews (SLAC) are awarded a grant for their project entitled: “Structural basis for high-affinity binding of a potent engineered angiogenesis inhibitor”

New graduate students Aaron Mitchell, Max Cherf, and Anne Ye join the lab.

Wallace H. Coulter Translational Partnership Award to treat ocular disease
Jennifer Cochran and Mark Blumenkranz receive funding to develop new protein-based biologics for treating ocular disease.

DOD Ovarian Cancer Award
Jennifer Cochran and Edward Graves are awarded a research grant from the Department of Defense to develop new diagnostic agents for ovarian cancer.

Review articles of interest
Current Opinion in Biotechnology
Methods in Enzymology
Drug Discovery Today

Jamie Bergen received a postdoctoral fellowship from the Stanford Children’s Health Research Institute

Jun Kim received a Nested Scholar Award from the Department of Defense for graduate studies in ovarian cancer research


2012

The Cochran lab welcomes Aaron Mitchell, Max Cherf, Mariya Chavarha, and Marcus Rohovie for a winter quarter rotation.

Graduate students Alan Leung and Cassie Liu present their research at the 2012 AiChe Meeting in Pittsburgh.

Jennifer Cochran was promoted to Associate Professor, with tenure, and has been named the Hitachi America Faculty Scholar in the Schools of Engineering and Medicine.

The Cochran lab welcomes Anne Ye, Joy Xiang, and Humsa Venkatesh to the lab for a fall quarter rotation.

Wallace H. Coulter Translational Partnership Award
Jennifer Cochran, Matthew Scott, Melanie Hayden Gephart, and Michael Edwards received funding to develop new molecular probes for image-guided tumor resection.

Bio-X Interdisciplinary Initiatives Program Seed Grant
Jennifer Cochran and Michelle Monje received a Bio-X IIP Seed grant to develop new therapeutic treatments for pediatric tumors.

DOD Prostate Cancer Idea Award
Professor Cochran is awarded a research grant from the Department of Defense to develop new diagnostic agents for prostate cancer.

The Cochran lab welcomes Christine Wang, Clarence Cheng, Bob Chen, Sungwon Lim, and Jenna Caldwell for a winter quarter rotation.

Recent review articles on knottin peptides
The Cochran lab publishes two review articles on engineered knottin peptides as therapeutic and diagnostic agents in Methods Enzymology and Drug Discovery Today.


2011

DOD Breast Cancer Idea Award
Professor Cochran is awarded a research grant from the Department of Defense to develop new therapeutics for treating breast cancer.

August

Dual-action protein better restricts blood vessel formation

See the press release.

In a publication in the Proceedings of the National Academy of Science, the Cochran lab engineered dual-specific proteins that more strongly inhibited angiogenic properties in vitro and in vivo compared to mono-specific proteins.

July

Engineered growth factor-based agonists and antagonists
In a publication in PNAS, the Cochran lab engineered stable fragments of hepatocyte growth factor that function as receptor agonists or antagonists for regenerative medicine or tissue engineering, respectively.


2010

February

Engineered Bispecific Proteins Pull Double Duty

A commentary in Science Translational Medicine on the state of engineered bispecific prpteins that recognize two different clinical targets. See the publications page for unrestricted access to the article.

 

January

Cochran and Giaccia receive Translational Partnership Award from the Wallace H. Coulter Foundation

Prof Jennifer Cochran and Prof Amato Giaccia were selected to receive a Coulter Foundation Translational Partnership Award for their project entitled "Engineered Receptor Tyrosine Kinase Decoys for Treatment of Metastatic Ovarian Cancer". Article.